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Disaster Magnet

Yesterday, we were all happily working in our labs.  We were running gels… incubating cells… conducting reactions… imaging results… and just generally doing things that require electricity.
Until the power blew, in a bang and the descent of instant darkness, followed by the humming and flickering of emergency lights and the klaxon screaming of irrelevant alarms.  As if we hadn’t figured out already that there was a problem of some sort.

The official procedure for any sort of alarm on campus is to leave the premises of whatever building you happen to be occupying at the time.  In our building (the “Crescent,” or main College of Medicine building), we have a set of heavy double doors that connect us to what is technically another building (the “BMR,” or biomedical research building) that is fully attached to ours.  In a true emergency situation, one would of course want to leave both buildings, but in most drills, we simply walk through the doors and follow the letter, rather than the spirit, of the law.

So we all wandered through the double doors and waited until they shut off the cacophony of warning signals and let us back into our own buildings.  No power, though, other than the emergency lights and a few bright red backup electrical outlets.  These are kind of vital, because there are millions of dollars’ worth of enzymes and cell cultures and reagents and samples occupying our refrigerators and freezers, and they cannot, under any circumstances, be allowed to sit at room temperature.  In some cases, they will simply be destroyed (a rather weak best-case scenario, considering that some of the cells have taken months or years to engineer, and some of the enzymes cost thousands of dollars per microlitre).  In other cases, it can actually be dangerous – some organic chemistry laboratories have compounds that become volatile or explosive at room temperature.

In any case, we spent the last half hour of our day (given that, of course, all of our experiments had been ruined due to the lack of power to operate the necessary equipment) wheeling giant refrigerators and specialty freezers around the hallways into the few labs that possessed red circuits, so that the massive power outage didn’t end up costing us more than a few days’ work.  We succeeded in the end, mostly, although we may have lost some of our minus-eighty-stored material (about four times colder than a regular freezer, the minus-eighties require a specialty plug that was incompatible with the emergency outlets).

In the end, we all went home for the weekend, only to have a “snow emergency” declared.  As of this morning, we’d receved fifteen inches of snow overnight, and it’s still falling.

Emergency, huh?  Back home, we just call that “winter.”

Yesterday

Yesterday was my birthday.  (Patton Oswalt would probably say that twenty-four is not actually a birthday* at all, since it’s kind of an unimportant age to be turning, but to that I say, “Ugh!  I’m in my mid-twenties!  I should take whatever pleasure I can, since I’m about to fall to dust here in my old age.”)  So there, Patton Oswalt.

Anyway, it was a good day, mostly.  Being in lab alone all morning was nice; having my three-day experiment fail utterly and simultaneously being unable to make the appropriate preparations for the next one was less nice.  Walking home in the not-very-cold-but-at-least-it’s-not-summer-weather-anymore was nice.  Cleaning my entire apartment top to bottom was nice.  Getting some schoolwork done was nice.  And getting my next Netflix rental DVD (four more episodes of Buffy the Vampire Slayer) was very nice.

But then I was picked up in a golden chariot (well, Lindsay’s red car) and driven to Red Lobster, where I was permitted to feast on shrimp and lobster to my heart’s content (yes, and Cheddar Bay biscuits.  Those are fantastic).  Following this, we went back to Christine’s apartment (where I was “not allowed to go into the kitchen”), and I was summarily presented with…

… a zombie dinosaur fossil cake.

Yes.

I know.

How cool are my friends?!

There were even cookies to go with it.

* Link contains a little profanity and politics.  It’s Patton Oswalt, after all.

Too Many Assignments…

… and so, again, I can’t write a proper entry.  But here are a few things!

Thing: I start my third rotation (in this lab) in a week and a half.  Technically, it was supposed to begin on Monday, but I’m taking an extra week to finish up the work I’ve been doing in this past rotation.  I’m going to learn how to use the rapid quench-flow system (a machine that lets me stop enzyme-catalyzed reactions on a millisecond time-scale, instead of by hand, when it takes several seconds at least)!  Hopefully, by the time I leave, I’ll have a nice set of results from which to calculate enzyme kinetics.
(I don’t know what my third rotation project will be, but I’m excited about starting in a more genetically-oriented lab.  It will also be the first time I’m in a more populated lab; there are three older graduate students and a technician in this one, and they always seem to be having fun!  At the same time, though, I’ve really enjoyed my second rotation.)

Thing: I have concluded that guys with names like Lindsey or Ashley are almost universally awesome.  Probably because at this point, those are relatively unpopular names for men, and so if you’re called that anyway, and you’re pulling it off, then chances are that it is because you are awesome.  (Case in point: my friend Courtney.  He is very awesome.)

I’m all out of things… so, in rapid conclusion: glycobiology is still hard, crystallography is over and we’re starting to study nuclear magnetic resonance tomorrow (yay physics!), and genetics is still both challenging and fun.  We’re about halfway through this first set of classes; in another few weeks, we’ll switch to the second set (I’ve already had to buy a textbook for some of them!).

I guess we’ll see how things go.

In Which I Talk a Lot and Hope That Someone Eventually Benefits From It

I don’t write very often about Asperger’s Syndrome (in fact, I don’t think I ever previously have), but I had a very unique experience in my first semester of graduate school – having been the first and only autistic student at the College – and I thought that I might offer a few observations in the hopes that it may help other students who are considering, or just starting out in, graduate school.  Not much information is readily available on this particular situation, it seems, or perhaps it is just that I have not been able to find it.
True, I have not been a graduate student for very long, and am in no way an expert.  However, I expect that the people who are most likely to look for this type of information are those who are in the position I very recently occupied; namely, those who are at the beginning of their graduate experience.  And so I pontificate.

*    *    *

1. Consider your school.

Every graduate school is different.  Some offer only one type of degree, while others offer many; some offer programs that may take one to three years, while others may take five to eight years.  Some schools have thousands of students and keep graduate and undergraduate students in the same areas; others may house graduate classes in separate buildings or even on separate campuses.  Some schools will fund you completely; others may offer partial scholarships or none at all.  Some will require you to teach or assist in order to maintain funding; some will not.  Think over what may be relevant to your needs both as a student and in terms of gaining future experience for your career (for instance, if you hope to become a professor one day, it may be advantageous to act as a teaching assistant during your graduate studies), and make sure that you apply to schools that meet the criteria you judge as most important to you.
Also consider factors that may make your day-to-day life easier or harder.  Perhaps you still receive a lot of assistance from your family, and wish to remain close to them or even continue living at home.  Perhaps you feel that you will be more successful in the familiar environment of your undergraduate school than if you were to tackle the challenges of a new university.  Or perhaps you want to make a clean break and start anew in a completely different place where you can be free of the challenges of your old school.  These factors can be extremely important for someone with Asperger’s Syndrome; the choice may not be as easy as simply asking yourself which school offers more funding or has a higher-rated program.

2. Consider your interests.

Your special interest(s) may not seem likely to lead to a graduate degree, or even to a career of any sort.  Look more closely, though; you may be surprised.  You may be able to turn a more generic field into something that specifically appeals to you by choosing to study in a certain program, work with a certain researcher, or take internships that address your interests while remaining relevant to your studies.  As a dedicated biologist with very little interest in chemistry, I found it difficult at first to cope with graduate studies in biochemistry.  However, I soon learned that by working with researchers who shared my interests in genetics, oncology and immunology, and by drawing links between what I learned in class and what I learned for interest’s sake, I could find a way to stay fascinated by my studies even when they were not always ideal.

3. Consider your field.

Don’t go to graduate school just because it’s what you were trained to do in undergraduate, or because it’s what you used to be interested in, or because it’s what’s expected of you.  You won’t enjoy it.  It will become increasingly difficult to tolerate the idea of “wasting your time” on something in which you have no interest.  Eventually, one of your special interests will take over and you won’t be spending time on your studies anymore (or perhaps no special interest will take over, but it will become so difficult to focus on uninteresting work that you will retreat from your studies).  Why do something you dislike?

So, in short, consider your special interest(s) when considering graduate school.  Make sure that you are attending because you really want to be studying there.

At the same time, though, it is important to consider where your educational field will lead.  What kinds of careers are available?  Will you be able to deal with the environment?  If possible, investigate the careers held by people with graduate degrees in your area.  If a lot of them involve dealing with other people, or working in noisy and crowded environments, you may wish to research other options with the possibility of more appealing working conditions.  It helps to know in advance that your years of hard work will lead to a job that you can enjoy both for its content and for its environment.

4. Get organized.

Your Asperger’s style may be neat and categorical, with “To-Do” lists, calendars, and neatly sorted school supplies.  In that case, you’re probably set.  On the other hand, your Asperger’s style may be to barely even notice your surroundings as you struggle to cope with the aspects of your life that seem so simple to neurotypical people – things like keeping track of when fees must be paid, when your car needs inspection, or why you need to wash your dishes when you still have a few clean ones left (or heck, maybe you can just re-use some of the less dirty ones).
The lifestyle changes that come with graduate school, especially if you are moving far from home or living alone or off-campus, are overwhelming.  The paperwork piles up, the appointments and meetings increase in number until you can barely remember when you are supposed to present at that Structural Biology Working Group conference, and the details take over.  But you don’t need to be dragged under – organization can make a complex life seem neat, clean, and most importantly, doable.

Buy yourself two calendars.  Have a wall calendar on which you mark important dates for meetings, appointments, and other things you want to remember.  That way, you will be able to glance up at it and remember that your committee meeting is in two weeks and you had better start preparing.  Have an academic planning calendar, too, that you carry around to your classes.  This is where you should write the details of assignments, topics to review, and anything that is important on a day-to-day basis.  Some students may prefer a computer- or web-based calendar to replace one or both of these tools; these can work, too, but make sure that you are able to make notes in them when assignments are given or thoughts occur to you.  A calendar is no good if you forget the dates and assignments before you can write them in.
Have a designated work area.  Keep school supplies (paper, pens, highlighters, and so on) close by, and make sure you have access to all of your textbooks.  You will want to have your computer and Internet access nearby, too, and a printer is helpful.  Make sure that, whatever your studying style, your work area is optimized for it.  Keep the rest of life elsewhere.
Keep documents organized.  This is not just for school (where you will be filing research papers, assignments, exams, lecture notes, and a hundred other things), but for daily life (where you will be filing bills, receipts, housing documents, insurance information, and a hundred other things) as well.
Set aside some time at least once a week to make sure that your surroundings are clean, your papers are filed, and you have sufficient school supplies and groceries to make it through the next little while.  It’s amazing how easy a little thing like needing to eat can be forgotten!

5. Don’t overestimate the social aspect of graduate school – but don’t underestimate it, either.

Chances are that in graduate school, your peers will be academically-oriented, and you will have (for the most part, at least) left behind the party-goers and time-wasters of your undergraduate experience.  This may make for a much more comfortable social environment, as your fellow students will share at least some of your interests, and are likely to be a calmer and more mature group of people.  Especially with the added freedom conferred by earning one’s own salary and making one’s own life decisions (for instance, you and many of your colleagues may live off-campus, or without roommates), this allows you to determine your own level of comfortable social interaction.
However, you may also find that you enjoy social events more with your graduate colleagues than previously.  They share common interests and experiences, have the same goals as you, and you may even find that some of them think just like you!  You may not be the only person in your graduate program who has arrived there by means of your Asperger’s special interest…

Whether or not it is easier or more pleasurable than in your undergraduate career, socialization serves a distinct purpose in graduate school.  Your fellow students come from a wide variety of backgrounds, and will thus bring a wide variety of skill sets to your class.  Where some of you may have a weakness, or insufficient background, others may be experts.  Collaboration is helpful, and makes getting through required classes (which may not correspond exactly to your interests) easier!  In addition, remember that all of these students will one day be authorities in your field.  Making and keeping connections now, however difficult it may be, allows you to have those contacts for the duration of your career.

6. What about accommodations?

If you received academic accommodations as an undergraduate, these may or may not continue in graduate school.  The larger the campus, especially if it houses undergraduates, the more likely you are to be able to establish whatever accommodations you need – be sure to make yourself familiar with your school’s disability services department.  Not only will you want to ensure that you can receive the services you need, but it is important to establish that you can work comfortably with the personnel in charge of administering those accommodations.  If you find it difficult to make your needs heard, you may be hesitant to initiate discussions when needed, and you may find yourself underserved.

Not all accommodations need to be formally established with disability services.  You may find it easier to request accommodations only when necessary, and to do so in person with the professor from whom the services are needed.  In order to avoid nasty surprises (such as discovering a week before the examination that the professor cannot help you without adequate documentation), mention to your professors at the start of the semester that you have Asperger’s Syndrome and have received accommodations in the past, so that you keep the possibility of further discussion open should it become necessary.

Some students who have never previously received accommodations may find that they become necessary during graduate studies, due to the increased difficulty of the coursework and the added responsibilities of being a mature student leading an “adult” lifestyle complete with paperwork, money, appointments, taxes, and a dozen other stressful items to process in a day.  On the other hand, some students who have received accommodations as undergraduates may find that, due to the change from a “teacher-to-student” to a “colleague-to-colleague” environment in graduate school, formal accommodations are no longer necessary.

In short, make sure that – if you feel you may need accommodations at some point – you investigate those options and make yourself comfortable with the system before making a final decision on a school, program or research supervisor.

*    *    *

I hope that my recent experiences can be of some help to other students in a similar position.  If there is anything I have omitted, or if there are unanswered questions about which I might have some small knowledge, please let me know.  I will do my best to consider them and come up with some sort of thoughtful answer.  Please bear in mind, however, that I speak only for the experiences I have had, and that your mileage may vary considerably.  (That is, I am not trying to imply that I am any sort of expert, or even particularly experienced.  I’m just trying to fill in a gap that I discovered when I could have used this type of information a semester or two ago and was singularly unable to find it.)

I don’t write very often about Asperger’s Syndrome (in fact, I don’t think I ever previously have), but I had a very unique experience in my first semester of graduate school – having been the first and only autistic student at the College – and I thought that I might offer a few observations in the hopes that it may help other students who are considering, or just starting out in, graduate school. Not much information is readily available on this particular situation, it seems, or perhaps it is just that I have not been able to find it.
True, I have not been a graduate student for very long, and am in no way an expert. However, I expect that the people who are most likely to look for this type of information are those who are in the position I very recently occupied; namely, those who are at the beginning of their graduate experience. And so I pontificate.

* * *

1. Consider your school.

Every graduate school is different. Some offer only one type of degree, while others offer many; some offer programs that may take one to three years, while others may take five to eight years. Some schools have thousands of students and keep graduate and undergraduate students in the same areas; others may house graduate classes in separate buildings or even on separate campuses. Some schools will fund you completely; others may offer partial scholarships or none at all. Some will require you to teach or assist in order to maintain funding; some will not. Think over what may be relevant to your needs both as a student and in terms of gaining future experience for your career (for instance, if you hope to become a professor one day, it may be advantageous to act as a teaching assistant during your graduate studies), and make sure that you apply to schools that meet the criteria you judge as most important to you.
Also consider factors that may make your day-to-day life easier or harder. Perhaps you still receive a lot of assistance from your family, and wish to remain close to them or even continue living at home. Perhaps you feel that you will be more successful in the familiar environment of your undergraduate school than if you were to tackle the challenges of a new university. Or perhaps you want to make a clean break and start anew in a completely different place where you can be free of the challenges of your old school. These factors can be extremely important for someone with Asperger’s Syndrome; the choice may not be as easy as simply asking yourself which school offers more funding or has a higher-rated program.

2. Consider your interests.

Your special interest(s) may not seem likely to lead to a graduate degree, or even to a career of any sort. Look more closely, though; you may be surprised. You may be able to turn a more generic field into something that specifically appeals to you by choosing to study in a certain program, work with a certain researcher, or take internships that address your interests while remaining relevant to your studies. As a dedicated biologist with very little interest in chemistry, I found it difficult at first to cope with graduate studies in biochemistry. However, I soon learned that by working with researchers who shared my interests in genetics, oncology and immunology, and by drawing links between what I learned in class and what I learned for interest’s sake, I could find a way to stay fascinated by my studies even when they were not always ideal.

3. Consider your field.

Don’t go to graduate school just because it’s what you were trained to do in undergraduate, or because it’s what you used to be interested in, or because it’s what’s expected of you. You won’t enjoy it. It will become increasingly difficult to tolerate the idea of “wasting your time” on something in which you have no interest. Eventually, one of your special interests will take over and you won’t be spending time on your studies anymore (or perhaps no special interest will take over, but it will become so difficult to focus on uninteresting work that you will retreat from your studies). Why do something you dislike?

So, in short, consider your special interest(s) when considering graduate school. Make sure that you are attending because you really want to be studying there.

At the same time, though, it is important to consider where your educational field will lead. What kinds of careers are available? Will you be able to deal with the environment? If possible, investigate the careers held by people with graduate degrees in your area. If a lot of them involve dealing with other people, or working in noisy and crowded environments, you may wish to research other options with the possibility of more appealing working conditions. It helps to know in advance that your years of hard work will lead to a job that you can enjoy both for its content and for its environment.

4. Get organized.

Your Asperger’s style may be neat and categorical, with “To-Do” lists, calendars, and neatly sorted school supplies. In that case, you’re probably set. On the other hand, your Asperger’s style may be to barely even notice your surroundings as you struggle to cope with the aspects of your life that seem so simple to neurotypical people – things like keeping track of when fees must be paid, when your car needs inspection, or why you need to wash your dishes when you still have a few clean ones left (or heck, maybe you can just re-use some of the less dirty ones).
The lifestyle changes that come with graduate school, especially if you are moving far from home or living alone or off-campus, are overwhelming. The paperwork piles up, the appointments and meetings increase in number until you can barely remember when you are supposed to present at that Structural Biology Working Group conference, and the details take over. But you don’t need to be dragged under – organization can make a complex life seem neat, clean, and most importantly, doable.

Buy yourself two calendars. Have a wall calendar on which you mark important dates for meetings, appointments, and other things you want to remember. That way, you will be able to glance up at it and remember that your committee meeting is in two weeks and you had better start preparing. Have an academic planning calendar, too, that you carry around to your classes. This is where you should write the details of assignments, topics to review, and anything that is important on a day-to-day basis. Some students may prefer a computer- or web-based calendar to replace one or both of these tools; these can work, too, but make sure that you are able to make notes in them when assignments are given or thoughts occur to you. A calendar is no good if you forget the dates and assignments before you can write them in.
Have a designated work area. Keep school supplies (paper, pens, highlighters, and so on) close by, and make sure you have access to all of your textbooks. You will want to have your computer and Internet access nearby, too, and a printer is helpful. Make sure that, whatever your studying style, your work area is optimized for it. Keep the rest of life elsewhere.
Keep documents organized. This is not just for school (where you will be filing research papers, assignments, exams, lecture notes, and a hundred other things), but for daily life (where you will be filing bills, receipts, housing documents, insurance information, and a hundred other things) as well.
Set aside some time at least once a week to make sure that your surroundings are clean, your papers are filed, and you have sufficient school supplies and groceries to make it through the next little while. It’s amazing how easy a little thing like needing to eat can be forgotten!

5. Don’t overestimate the social aspect of graduate school – but don’t underestimate it, either.

Chances are that in graduate school, your peers will be academically-oriented, and you will have (for the most part, at least) left behind the party-goers and time-wasters of your undergraduate experience. This may make for a much more comfortable social environment, as your fellow students will share at least some of your interests, and are likely to be a calmer and more mature group of people. Especially with the added freedom conferred by earning one’s own salary and making one’s own life decisions (for instance, you and many of your colleagues may live off-campus, or without roommates), this allows you to determine your own level of comfortable social interaction.
However, you may also find that you enjoy social events more with your graduate colleagues than previously. They share common interests and experiences, have the same goals as you, and you may even find that some of them think just like you! You may not be the only person in your graduate program who has arrived there by means of your Asperger’s special interest…

Whether or not it is easier or more pleasurable than in your undergraduate career, socialization serves a distinct purpose in graduate school. Your fellow students come from a wide variety of backgrounds, and will thus bring a wide variety of skill sets to your class. Where some of you may have a weakness, or insufficient background, others may be experts. Collaboration is helpful, and makes getting through required classes (which may not correspond exactly to your interests) easier! In addition, remember that all of these students will one day be authorities in your field. Making and keeping connections now, however difficult it may be, allows you to have those contacts for the duration of your career.

6. What about accommodations?

If you received academic accommodations as an undergraduate, these may or may not continue in graduate school. The larger the campus, especially if it houses undergraduates, the more likely you are to be able to establish whatever accommodations you need – be sure to make yourself familiar with your school’s disability services department. Not only will you want to ensure that you can receive the services you need, but it is important to establish that you can work comfortably with the personnel in charge of administering those accommodations. If you find it difficult to make your needs heard, you may be hesitant to initiate discussions when needed, and you may find yourself underserved.

Not all accommodations need to be formally established with disability services. You may find it easier to request accommodations only when necessary, and to do so in person with the professor from whom the services are needed. In order to avoid nasty surprises (such as discovering a week before the examination that the professor cannot help you without adequate documentation), mention to your professors at the start of the semester that you have Asperger’s Syndrome and have received accommodations in the past, so that you keep the possibility of further discussion open should it become necessary.

Some students who have never previously received accommodations may find that they become necessary during graduate studies, due to the increased difficulty of the coursework and the added responsibilities of being a mature student leading an “adult” lifestyle complete with paperwork, money, appointments, taxes, and a dozen other stressful items to process in a day. On the other hand, some students who have received accommodations as undergraduates may find that, due to the change from a “teacher-to-student” to a “colleague-to-colleague” environment in graduate school, formal accommodations are no longer necessary.

In short, make sure that – if you feel you may need accommodations at some point – you investigate those options and make yourself comfortable with the system before making a final decision on a school, program or research supervisor.

* * *

I hope that my recent experiences can be of some help to other students in a similar position. If there is anything I have omitted, or if there are unanswered questions about which I might have some small knowledge, please let me know. I will do my best to consider them and come up with some sort of thoughtful answer. Please bear in mind, however, that I speak only for the experiences I have had, and that your mileage may vary considerably. (That is, I am not trying to imply that I am any sort of expert, or even particularly experienced. I’m just trying to fill in a gap that I discovered when I could have used this type of information a semester or two ago and was singularly unable to find it.)

Jürgen Prochnow

So my friend Matt and I were watching Eddie Izzard’s Definite Article yesterday, and we were specifically enjoying the part where he compares the impenetrability of an orange to the movie Das Boot:

” ‘Cause inside an orange – it’s like the film Das Boot in there! With Jürgen Prochnow going, “Don’t let zem get into ze orange! It’s most important! Or ze juice will get out, and it’ll not be good. Zey’re breaking in with fingers, depth charges! Let ze peel come off only in small chunks! … Zey’re breaking in! Push all ze pips into bits zey wouldn’t expect!”

And from that experience, and subsequent conversation, this arose:

"Don't let zem get into ze orange!"

Yeah.

If this ridiculousness is intriguing to you, the audio recording of the show can be found here – however, I’d recommend watching the video, if at all possible.

(Side note: I know that’s not Jürgen Prochnow in my orange; it’s Erwin Leder.  But all the images of Jürgen Prochnow were from the wrong angle and just too stoic, so I went with something more in the spirit of the thing.)

Did I Blink Or Something?

What happened to winter?

Is this seriously what Pennsylvania looks like in January?

Where is the snow?  The wind?  Where are the thirty-below temperatures?  How is there grass?  How is there sun?  I’m overheating in my freaking T-shirt, it’s so warm.

Does this state even have a winter, or was it all a lie?

Exhausting

Classes are… well, they’re progressing, at least.  In some of them, I actually have an idea as to what’s going on.  In others, I don’t think there’s a metaphor strong enough to express how hopeless I am (yes, after one week).  It is a fairly intensive chemistry class (in which my only two classmates have majors and minors in chemistry), and I am, simply put, a biologist.  (With a minor in philosophy, no less.)

However, when I explained to one of my future biochemistry rotation supervisors how I was feeling about the class, concluding with “I’m not really a chemist,” he glanced furtively around the hallway and then told me in a low voice, “I’m not either,” accompanied by a wink.  “Don’t tell anyone.”

I’m glad he’s going to supervise one of my rotations.

Lab work is coming along, too.  I’ve been doing the same experiment, with slight modifications to refine the data, for over a week now, but the results are starting to make a decent picture of how we think our enzyme functions.  Hopefully, it’ll be clean and complete soon, so that we can continue to make headway.  (But hey!  I’m getting pretty good at pouring sequencing gels.)

However, between classes and research, it has been practically impossible to take even a deep breath lately.  Perhaps it will become less stressful soon.

And in other news: it’s warm here, I’m on Testchamber 17 of Portal, I’m on Season 2 of Buffy the Vampire Slayer and Season 3 of Dexter, I’m reading Carl Sagan and L.M. Montgomery, and in a few weeks, I will start my third rotation in this lab (three cheers for human genetics and X-inactivation!).

Okay, I know I’ve been away for too long when WordPress actually forgets who I am.

In any case, lab work has been all-consuming lately (all right, fine, lab work and Dexter and cleaning and reading scientific papers for my new classes) (okay, and maybe also Buffy the Vampire Slayer I know I know but it’s Joss Whedon so how can I resist?!).

But the new semester begins tomorrow, and honest to goodness, it’s going to  be the most difficult thing I’ve ever done.  Even more so than this past semester has been.  I am taking seven courses, in addition to the biochemistry and molecular biology colloquium, the departmental seminar, and my laboratory rotations.  Unexpectedly, I and the other two students in my department were not given the option of any elective courses – all of these were chosen by our department and assigned to us.  That has made me rather sad lately, and I am basically just hoping to make it to next semester so that I can start work on some of the things that really deeply interest me.

Three of the courses are a series in enzymology:
- Enzymology (Structure): Protein structure and the tools to determine objectively the quality of an experimentally-determined structure. The basic principles underlying X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, and how to assess the quality of a structure determined by these techniques.
- Enzymology (Energetics): Protein-protein, protein-ligand and enzyme-substrate interactions defining how cells respond to external signals and maintain homeostasis, and the methods used to analyze these complex interactions.
- Enzymology (Function): The various mechanisms of enzyme catalysis, and literature-based analyses of specific enzymes that use the various mechanisms.

A fourth course is in glycobiology, which is just… hard:
- Glycobiology (Carbohydrate Chemistry): Because of their structure and the ability of just two sugars to form a number of different bonds with one another, carbohydrate chemistry is significantly more complex than that of any of the other building blocks found in the body.  The course deals with the basics of carbohydrate chemistry and with glycomics.

The final three courses are in genetics.  These ones may be at least manageable:
- Genetics of Model Organisms (Molecular Genetic Analysis of Signalling Pathways): The principles that make molecular genetic analysis a critical tool for identifying and characterizing components and functions of biological pathways, with a specific focus on signalling pathways (and a specific focus on Saccharomyces cerevisiae as the lower eukaryotic model organism of choice).
- Genetics of Model Organisms (Bacterial and Viral Pathogenesis): The principles of molecular genetic analysis of bacteria and their viruses and other genetic elements, including examples from current literature illustrating principles and approaches to the study of bacterial genetics with a specific focus on bacterial pathogenesis.
- Topics in Human Genetics: DNA repair pathologies, trinucleotide repeat disorders, epigenetic diseases and genomic imprinting, epigenetic diseases and the environment, and finally a study on a possible epigenetic disorder, Rett Syndrome.  (Actually, that part should be fascinating.)

So, as I said… I’m just hoping to make it to next semester.  Wish me luck, please.

Ohmygoshwow!

Long absence.  Why?  Trip to Edmonton!

The day I arrived (well, I got in at one o’clock in the morning, having travelled half of the distance on a tiny, eighteen-seater propeller plane, and became functional about seven hours later) I went out to Starbucks with the girls and then watched The Polar Express on a massive basement television in surround sound, after which Scattergories was played and awesomeness had (*gasp – long sentence*).  Following this was Christmas dinner and gifts with my parents and brother, and the watching of the first few episodes of Castle, a show I would really like my parents to watch and enjoy on a regular basis.  (I mean, come on, doesn’t Nathan Fillion deserve a show that runs for more than one season… for once?)

Christmas Day was spent re-watching Castle (jet-lagged parents had fallen asleep the first time around) and fixing computers for various technologically-differently-abled persons.  I went to Christmas dinner again in the evening, this time at the home of Alicia, a friend from the Sundance Housing Co-op.  Paul and I then went to pick Jason up at the airport, failing utterly to surprise him with our (apparently-not-so-) cleverly-developed story of a taxi driver who would meet him at the doors and take him home.  (We even made a sign for the “taxi driver” with his name on it!)

The rest of the week is a whirlwind of visiting West Edmonton Mall, watching Dexter (ohmygoshwow), fixing more computers, showing my parents The Illusionist (one of my favourite movies; you should really watch it if you haven’t already), going on a gourmet cheese shopping spree (eaten, like a true connoisseur, with four-dollar crackers from Safeway), more Dexter (ohmygoshwow), listening to Jason’s rants about the cold and the snow and the terrible driving conditions, stopping in at MEC (of course), playing Pure and Halo 3 on my new Xbox 360 (way to go, Boxing Day), and more Dexter (ohmygosh… well, you know the drill by now).  It was non-stop busy, incredibly amazing, and reminded me of why I belong in the frozen, hostile wasteland of northern Alberta.

… Maybe one day.  In the meantime, here are pictures…

Merry Christmas

Merry Christmas, everyone!

I hope yours are all as wonderful as mine is shaping up to be.

(Not wanting to be culturally insensitive, I wish all of you the best of holidays, regardless of what – if anything – you are celebrating.  It just happens to be Christmas today, whereas Hannukah is already over and Kwanzaa has not yet begun.  However, if either of those is your choice of holiday – enjoy it!)

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